Metabolismo parte I
-
Upload
thamarita91 -
Category
Health & Medicine
-
view
78 -
download
4
Transcript of Metabolismo parte I
![Page 1: Metabolismo parte I](https://reader033.fdocuments.mx/reader033/viewer/2022042602/55ad3b931a28abd57b8b46dc/html5/thumbnails/1.jpg)
METABOLISMO PARTE I
![Page 2: Metabolismo parte I](https://reader033.fdocuments.mx/reader033/viewer/2022042602/55ad3b931a28abd57b8b46dc/html5/thumbnails/2.jpg)
CATABOLISMO
DEGRADACIÓN
OXIDACIÓN
EXERGONIA
Moléculas
complejas,
reducidas
Cofactores oxidados
Moléculas de menor
tamaño, oxidadas
Cofactores reducidos
ATP
SÍNTESIS
REDUCCIÓN
ENDERGONIA
ANABOLISMO
METABOLISMO
![Page 3: Metabolismo parte I](https://reader033.fdocuments.mx/reader033/viewer/2022042602/55ad3b931a28abd57b8b46dc/html5/thumbnails/3.jpg)
METABOLISMO
A B C DSUSTRATO PRODUCTOMETABOLITOS
E
F
G H
I J
K
L
M
NO
![Page 4: Metabolismo parte I](https://reader033.fdocuments.mx/reader033/viewer/2022042602/55ad3b931a28abd57b8b46dc/html5/thumbnails/4.jpg)
METABOLISMO
OH
CH2OH
OH
OH
HO
H
OH
CH2 O P
OH
OH
HO
H
ATP ADP
Mg2+
HEXOQUINASA
![Page 5: Metabolismo parte I](https://reader033.fdocuments.mx/reader033/viewer/2022042602/55ad3b931a28abd57b8b46dc/html5/thumbnails/5.jpg)
METABOLISMOGLUCÓLISIS
1.Formación de Glucosa-6-fosfato
Glucosa
HEXOQUINASA
Glucosa-6-P
GlucógenoFOSFORILASA
Glucosa-1-P FOSFOGLUCOMUTASA
![Page 6: Metabolismo parte I](https://reader033.fdocuments.mx/reader033/viewer/2022042602/55ad3b931a28abd57b8b46dc/html5/thumbnails/6.jpg)
METABOLISMOGLUCÓLISIS
2.Formación de Fructosa-6-fosfato
Mg2+
o Mn2+
FOSFOGLUCOMUTASA
OH
CH2 O P
OH
OH
HO
H
CH2 CH2OH
OH
OHHO
O
P
![Page 7: Metabolismo parte I](https://reader033.fdocuments.mx/reader033/viewer/2022042602/55ad3b931a28abd57b8b46dc/html5/thumbnails/7.jpg)
METABOLISMOGLUCÓLISIS
3.Fosforilación de Fructosa-6-fosfato
CH2 CH2OH
OH
OHHO
O
P
FOSFOFRUCTOQUINASA
ATP ADP
Mg2+
CH2 CH2
OH
OHHO
O
P
O
P
![Page 8: Metabolismo parte I](https://reader033.fdocuments.mx/reader033/viewer/2022042602/55ad3b931a28abd57b8b46dc/html5/thumbnails/8.jpg)
METABOLISMOGLUCÓLISIS
4.Formación de Triosas-fosfatoCH2 CH2
OH
OHHO
OP O P
ALDOLASA
H
C O
H C OH
CH2 O P
Gliceraldehído-3-P
CH2OH
C O
CH2 O P
Dihidroxiacetona-3-P
![Page 9: Metabolismo parte I](https://reader033.fdocuments.mx/reader033/viewer/2022042602/55ad3b931a28abd57b8b46dc/html5/thumbnails/9.jpg)
METABOLISMOGLUCÓLISIS
5.Interconversión de Triosas-fosfato
H
C O
H C OH
CH2 O P
CH2OH
C O
CH2 O P
TRIOSA-FOSFATOISOMERASA
![Page 10: Metabolismo parte I](https://reader033.fdocuments.mx/reader033/viewer/2022042602/55ad3b931a28abd57b8b46dc/html5/thumbnails/10.jpg)
METABOLISMOGLUCÓLISIS
6.Oxidación y fosforilación de G-3-P
H
C O
H C OH
CH2 O P
G-3-P DESHIDROGENASA
NAD+ NADH+H
+Pi
CH2 O P
CH.OH
CO.O ~ P
1,3-bifosfoglicerato
![Page 11: Metabolismo parte I](https://reader033.fdocuments.mx/reader033/viewer/2022042602/55ad3b931a28abd57b8b46dc/html5/thumbnails/11.jpg)
METABOLISMOGLUCÓLISIS
7.Fosforilación a nivel del sustrato
FOSFOGLICERATO
QUINASACH2 O P
CH.OH
CO.O ~ PADP ATP
Mg2+
CH2 O P
CH.OH
CO.O-
3-fosfoglicerato
![Page 12: Metabolismo parte I](https://reader033.fdocuments.mx/reader033/viewer/2022042602/55ad3b931a28abd57b8b46dc/html5/thumbnails/12.jpg)
METABOLISMOGLUCÓLISIS
8.Formación de 2-fosfoglicerato
FOSFOGLICEROMUTASA CH2.OH
CH O P
CO.O-
2-fosfoglicerato
Mg2+
CH2 O P
CH.OH
CO.O-
![Page 13: Metabolismo parte I](https://reader033.fdocuments.mx/reader033/viewer/2022042602/55ad3b931a28abd57b8b46dc/html5/thumbnails/13.jpg)
METABOLISMOGLUCÓLISIS
9.Formación de fosfoenolpiruvato
ENOLASACH2.OH
CH O P
CO.O-
Mg2+
CH2
CH O~ P + H2O
CO.O-
Fosfoenolpiruvato
![Page 14: Metabolismo parte I](https://reader033.fdocuments.mx/reader033/viewer/2022042602/55ad3b931a28abd57b8b46dc/html5/thumbnails/14.jpg)
METABOLISMOGLUCÓLISIS
10.Segunda fosforilación a nivel de
sustrato
PIRUVATO QUINASACH2
CH O~ P
CO.O-
CH2
C OH
CO.O-
enolpiruvatoADP ATP
Mg2+
K+
CH3
C O
CO.O-
piruvato
![Page 15: Metabolismo parte I](https://reader033.fdocuments.mx/reader033/viewer/2022042602/55ad3b931a28abd57b8b46dc/html5/thumbnails/15.jpg)
METABOLISMOGLUCÓLISIS
11.Formación de lactato
CH3
C O
CO.O-
LACTATO
DESHIDROGENASA
NAD+
NADH+H+
CH3
CH.OH
CO.O-
lactato
![Page 16: Metabolismo parte I](https://reader033.fdocuments.mx/reader033/viewer/2022042602/55ad3b931a28abd57b8b46dc/html5/thumbnails/16.jpg)
METABOLISMOGLUCÓLISIS
![Page 17: Metabolismo parte I](https://reader033.fdocuments.mx/reader033/viewer/2022042602/55ad3b931a28abd57b8b46dc/html5/thumbnails/17.jpg)
METABOLISMODESCARBOXILACIÓN OXIDATIVA DEL
PIRUVATO
![Page 18: Metabolismo parte I](https://reader033.fdocuments.mx/reader033/viewer/2022042602/55ad3b931a28abd57b8b46dc/html5/thumbnails/18.jpg)
METABOLISMOCICLO DE KREBS
![Page 19: Metabolismo parte I](https://reader033.fdocuments.mx/reader033/viewer/2022042602/55ad3b931a28abd57b8b46dc/html5/thumbnails/19.jpg)
METABOLISMOCADENA RESPIRATORIA
![Page 20: Metabolismo parte I](https://reader033.fdocuments.mx/reader033/viewer/2022042602/55ad3b931a28abd57b8b46dc/html5/thumbnails/20.jpg)
METABOLISMOCADENA RESPIRATORIA
![Page 21: Metabolismo parte I](https://reader033.fdocuments.mx/reader033/viewer/2022042602/55ad3b931a28abd57b8b46dc/html5/thumbnails/21.jpg)
METABOLISMOCADENA RESPIRATORIA
![Page 22: Metabolismo parte I](https://reader033.fdocuments.mx/reader033/viewer/2022042602/55ad3b931a28abd57b8b46dc/html5/thumbnails/22.jpg)
METABOLISMOCADENA RESPIRATORIA
![Page 23: Metabolismo parte I](https://reader033.fdocuments.mx/reader033/viewer/2022042602/55ad3b931a28abd57b8b46dc/html5/thumbnails/23.jpg)
METABOLISMOBALANCE ENERGÉTICO
ETAPA Nº DE MOLES DE ATP
GLUCÓLISIS 6 u 8
DESCARBOXILACIÓN OXIDATIVA
DEL PIRUVATO6
CICLO DE KREBS 24
TOTAL 36 o 38