Lista de Bases de Datos

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    PRINCIPALES BASES DE DATOS DE SECUENCIAS DE DNA

    DDBJ(http://www.ddbj.nig.ac.jp/index-e.html)

    DDBJ (DNA Data Bank of Japan) is one of the three summit databanks thatconstruct DDBJ/EMBL/GenBank Internationa Nuceotide !e"uence Database#throu$h cose coaboration %ith EBI in Europe and N&BI in '!ADDBJ is the soe DNA data bank in Japan# %hich is officia certified to coectDNA se"uences from researchers and to issue the internationa reco$ni*edaccession number to data submitters +e coect data main from Japaneseresearchers# but of course accept data and issue the accession number toresearchers in an other countries !ince %e e,chan$e the coected data %ithEMBL/EBI and GenBank/N&BI on a dai basis# the three data banks share-irtua the same data at an $i-en time.

    EMBL-Bank(http://www.ebi.ac.uk/embl)

    .he database is produced in an internationa coaboration%ith GenBank ('!A)and the DNA Database of Japan (DDBJ) Each of the three $roups coects aportion of the tota se"uence data reported %ord%ide# and a ne% and updateddatabase entries are e,chan$ed bet%een the $roups on a dai basis.he EMBL Nuceotide !e"uence Database (aso kno%n as EMBLBank)constitutes Europe0s primar nuceotide se"uence resource Main sources forDNA and 1NA se"uences are direct submissionsfrom indi-idua researchers#

    $enome se"uencin$ pro2ects and patent appications

    enBank(http://www.ncbi.nlm.nih.g!"/Ent#e$/)

    GenBank is part of the Internationa Nuceotide !e"uence Database&oaboration# %hich comprises the DNA DataBank of Japan (DDBJ)# theEuropean Moecuar Bioo$ Laborator (EMBL)# and GenBank at N&BI .hesethree or$ani*ations e,chan$e data on a dai basisGenBank3is the NI4 $enetic se"uence database# an annotated coection of apubic a-aiabe DNA se"uences .here are appro,imate 56#768#659#79:

    bases in 5;#56>5

    PRINCIPALES BASES DE DATOS DE TAXONOMA%#ee !& Li&e 'eb #!ject (http@//%%%to%ebor$/tree/pho$enhtm)

    .he .ree of Life +eb ro2ect is a coection of information about biodi-ersitcompied coaborati-e b hundreds of e,pert and amateur contributors Its$oa is to contain a pa$e %ith pictures# te,t# and other information for e-erspecies and for each $roup of or$anisms# i-in$ or e,tinct &onnections bet%een

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    http://www.ddbj.nig.ac.jp/index-e.htmlhttp://www.ebi.ac.uk/emblhttp://www.ebi.ac.uk/embl/Contact/collaboration.htmlhttp://www.ebi.ac.uk/embl/Submission/index.htmlhttp://www.ncbi.nlm.nih.gov/Entrez/http://www.ncbi.nlm.nih.gov/projects/collab/http://www.ncbi.nlm.nih.gov/projects/collab/http://www.tolweb.org/tree/phylogeny.htmlhttp://www.tolweb.org/tree/home.pages/people.htmlhttp://www.ddbj.nig.ac.jp/index-e.htmlhttp://www.ebi.ac.uk/emblhttp://www.ebi.ac.uk/embl/Contact/collaboration.htmlhttp://www.ebi.ac.uk/embl/Submission/index.htmlhttp://www.ncbi.nlm.nih.gov/Entrez/http://www.ncbi.nlm.nih.gov/projects/collab/http://www.ncbi.nlm.nih.gov/projects/collab/http://www.tolweb.org/tree/phylogeny.htmlhttp://www.tolweb.org/tree/home.pages/people.html
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    .ree of Life %eb pa$es foo% pho$enetic branchin$ patterns bet%een $roupsof or$anisms# so -isitors can bro%se the hierarch of ife and earn aboutpho$en and e-oution as %e as the characteristics of indi-idua $roups

    pecie* +,,,(http@//%%%sp;>>>or$)

    !pecies ;>>> (%%%sp;>>>or$) is an autonomous federation of ta,onomicdatabase custodians# in-o-in$ ta,onomists throu$hout the %ord Its $oa is tocoate a uniform and -aidated inde, to the %ord0s kno%n species It is a notforprofit compan imited b $uarantee (re$istered in En$and No 6)%ith si, directors and ta,onomic database or$anisations from around the %ordas members It is sponsored b &DA.A# I'B! and I'M!C is an associateparticipant in GBI?C and is reco$nised b 'NE and the &BD .here are t%ore$iona pro$rammes@ !pecies ;>>> europa (sp;>>>europaor$)# %orkin$ %ith$oba and re$iona databases based in Europe and !pecies ;>>> Asiaceania (%%%sp;>>>aonies$o2p) %orkin$ to promote ta,onom and

    ta,onomic databasin$ in that re$ion .he hase II ro$ramme is estabishin$ anumber of re$iona/nationa hubs of %hich the European 4ub# the !pecies ;>>>&hina Node (%%%sp;>>>cn)# the Bra*iian 4ub (E &atao$o da ida Bra*i )and the N America 4ub are the first to appear

    PRINCIPALES BASES DE DATOS DE RNA

    %he '!#ld 'eb*ite(http@//%%%imb2enade/1NAhtm)

    .his %eb resource ists Internet inks on 1NA reated topics

    0 #ib!*!mal Databa*e(http@//%%%manpo*nanp/6!Data/)

    6! ribosoma 1NA is an inte$ra component of the ar$e subunit of actopasmic and most or$anear ribosomes Its sma si*e and association %ithribosoma as %e as nonribosoma proteins made it an idea mode 1NAmoecue for studies of 1NA structure and 1NAprotein interactions

    .he purpose of this database is to pro-ide information on nuceotide se"uencesof 6! r1NAs and their $enes .he se"uences for particuar or$anisms can be

    retrie-ed as sin$e fies usin$ a ta,onomic bro%ser or in mutipe se"uencestructura ai$nments

    tDB: %he en!mic t Databa*e(http@//rna%ustedu/t1NAdb/)

    .his $enomic t1NA database contains t1NA $ene predictions made b thepro$ram t1NAscan!E on compete or near compete $enomes 'nessother%ise noted# a annotation is automated# and has not been inspected fora$reement %ith pubished iterature

    1L2: 3!mp#ehen*i"e #ib!*!mal databa*e*(http@//%%%arbsi-ade/)

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    http://www.sp2000.org/http://www.sp2000.org/http://www.sp2000europa.org/http://www.sp2000ao.nies.go.jp/http://www.sp2000.cn/http://www.imb-jena.de/RNA.htmlhttp://www.bioexplorer.net/cgi-bin/links/jump.pl?ID=706http://www.man.poznan.pl/5SData/http://www.bioexplorer.net/cgi-bin/links/jump.pl?ID=1584http://var/www/apps/conversion/tmp/scratch_4/(http://rna.wustl.edu/tRNAdb/http://www.arb-silva.de/http://www.sp2000.org/http://www.sp2000.org/http://www.sp2000europa.org/http://www.sp2000ao.nies.go.jp/http://www.sp2000.cn/http://www.imb-jena.de/RNA.htmlhttp://www.bioexplorer.net/cgi-bin/links/jump.pl?ID=706http://www.man.poznan.pl/5SData/http://www.bioexplorer.net/cgi-bin/links/jump.pl?ID=1584http://var/www/apps/conversion/tmp/scratch_4/(http://rna.wustl.edu/tRNAdb/http://www.arb-silva.de/
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    A comprehensi-e onine resource for "uait checked and ai$ned ribosoma1NA se"uence data# free for academic use !ILA pro-ides comprehensi-e#"uait checked and re$uar updated databases of ai$ned sma (=9!/=5!#!!') and ar$e subunit (; peope are in-o-ed throu$h different tasks such as databasecuration# soft%are de-eopment and support'nti a fe% ears a$o# EBI and !IB to$ether produced !%issrot and .rEMBL#%hie I1 produced the rotein !e"uence Database (I1!D) .hese t%odata sets coe,isted %ith different protein se"uence co-era$e and annotationpriorities .rEMBL (.ransated EMBL Nuceotide !e"uence Data Librar) %asori$ina created because se"uence data %as bein$ $enerated at a pace thate,ceeded !%issrot0s abiit to keep up Mean%hie# I1 maintained the I1!D and reated databases# incudin$ iro&ass# a database of proteinse"uences and curated famiies In ;>>; the three institutes decided to pootheir resources and e,pertise and formed the 'nirot &onsortium

    1 - #!tein 1n&!#mati!n e*!u#ce(http@//pir$eor$eto%nedu)

    .he rotein Information 1esource (I1)# in coaboration %ith the MunichInformation &enter for rotein !e"uences (MI!) and the JapaneseInternationa rotein !e"uence Database (JIID) maintains the I1Internationa rotein !e"uence Database a comprehensi-e# annotated# andnonredundant set of protein se"uence databases in %hich entries are cassifiedinto fami $roups and ai$nments of each $roup are a-aiabe

    DB - %he #!tein Data Bank(http@//%%%rcsbor$/pdb/)

    An internationa repositor for the processin$ and distribution of

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    .he rotein Mutant Database (MD) co-ers natura as %e as artificia mutants#incudin$ random and sitedirected ones# for a proteins e,cept members of the$obin and immuno$obuin famiies .he MD is based on iterature# not onproteins .hat is# each entr in the database corresponds to one artice %hichma describe one# se-era or a number of protein mutants

    1nte##! (http@//%%%ebiacuk/interpro)

    Interro is a database of protein famiies# domains# re$ions# repeats and sites in%hich identifiabe features found in kno%n proteins can be appied to ne%protein se"uences Interro =8> is reeased and co-ers 79; of 'nirotB#%ith ne% methods from fam# AN.4E1# Gene

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    B1ENDA is the main coection of en*me functiona data a-aiabe to thescientific communit .he en*mes are cassified accordin$ to the En*me&ommission ist of en*mes !ome :>>> different en*mes are co-ered

    En$7me* and metab!lic pathwa7*(http@//i$%ebinte$rated$enomicscom/M+/)

    .he EM ro2ect# Inc %as incorporated in =888 to pro-ide or$ani*ationa# e$a#and financia support for the EM $roup pro2ects# such as En*mes andMetaboic ath%as Database (EM) and Metaboic ath%as Database(M+) EM/M+ is the most comprehensi-e sin$e source of computeri*edbiochemica data a-aiabe toda Moreo-er# this is a po%erfu too for metaboicreconstruction and modein$# unmatched in either academia or the $enomicsindustr Both databases are current used in a number of pubic andcommercia $enomics pro2ects

    6E: 67!t! Enc7cl!pedia !& ene* and en!me*(http@//%%%$enome2p/ke$$/))

    A $rand chaen$e in the post$enomic era is a compete computerrepresentation of the ce# the or$anism# and the biosphere# %hich %i enabecomputationa prediction of hi$here-e compe,it of ceuar processes andor$anism beha-iors from $enomic and moecuar information .o%ards this end%e ha-e been de-eopin$ a bioinformatics resource named EGG as part of theresearch pro2ects of the anehisa Laboratories in the Bioinformatics &enter of

    oto 'ni-ersit and the 4uman Genome &enter of the 'ni-ersit of .oko

    %he 4ni"e#*it7 !& Minne*!ta Bi!catal7*i*/Bi!deg#adati!n Databa*e(http@//umbbdmsiumnedu/)

    .he 'ni-ersit of Minnesota Biocatasis/Biode$radation Database ('MBBD)contains compound# en*me# reaction and path%a information for microbiacataboism of primari anthropo$enic materias It has been a-aiabe on the%eb for o-er => ears# and has $ro%n from : to amost =6> path%as As it

    starts its second decade# the 'MBBD contains information on o-er 8>>compounds# o-er 9>> en*mes# near =>>> reactions and about microor$anism entriesAon$ %ith path%a data# the 'MBBD no% incudes Biochemica eriodic.abes and a Biode$radation ath%a rediction !stem (!) ItsBiochemica eriodic .abes ha-e $ro%n to incude bioo$ica information foramost a stabe# nonnobe$as eements# and an KAbout the Biochemicaeriodic .abes %eb pa$e has been created(http@//umbbdahcumnedu/periodic/) .he !(http@//umbbdahcumnedu/predict/) is no% an internationa reco$ni*ed# opensstem for predictin$ microbia cataboism of or$anic compounds

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    http://igweb.integratedgenomics.com/MPW/http://www.genome.ad.jp/kegg/http://www.genome.jp/kegg/http://umbbd.msi.umn.edu/http://igweb.integratedgenomics.com/MPW/http://www.genome.ad.jp/kegg/http://www.genome.jp/kegg/http://umbbd.msi.umn.edu/
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    BASES DE DATOS DE ORGANISMOS MODELO

    %he 5#gani*m Databa*e(http@//safbiocatechedu/modeor$htm)

    .his pa$e contains inks to sin$e or$anism databases

    %1 Databa*e(http@//%%%ti$ror$/dbshtm)

    .IG10s Genome ro2ects are a coection of curated databases containin$ DNAand protein se"uence# $ene e,pression# ceuar roe# protein fami# andta,onomic data for microbes# pants and humans .he access to the data isfaciitated b .IG10s Internet hi$hspeed research net%ork connection %hich issupported in part b the Nationa !cience ?oundation ('!A)

    E*che#ichia c!li

    E. c!li en!me #!ject(http@//%%%$enome%iscedu/)

    4a-in$ se"uenced the E coi =; $enome# %e no% maintain and update itsannotation +e are creatin$ a knockout of e-er $ene# a cone of e-er 1?#and an e,tensi-e $ene e,pression data set under a -ariet of phsioo$icaconditions .hese cones and data sets are made a-aiabe free to thecommunit +e ha-e aso se"uenced si, additiona enterobacteria strains%hich are patho$ens cose reated to E coi =;# and man pasmids .hecomparati-e $enomics aim of this effort is to characteri*e the $ene poo ofhori*onta transferred eements and -iruence determinants kno%n as the

    pathosphere

    33: %he 3!li enetic t!#e 3ente#(http@//c$scbioo$aeedu/inde,php)

    .he &G!& Database of E coi $enetic information incudes $enotpes andreference information for the strains in the &G!& coection# the names#snonms# properties# and map position for $enes# $ene product information#and information on specific mutations and references to primar iterature .he&G!& &oection contains on nonpatho$enic aborator strains# primari$enetic deri-ati-es of Escherichia coi =;# the aborator strain %ide used in$enetic and moecuar studies

    accha#!m7ce* ce#e"i*eae

    D: accha#!m7ce* en!me Databa*e(http@//%%%east$enomeor$/)

    !GD is an or$ani*ed coection of $enetic and moecuar bioo$ica informationabout !accharomces cere-isiae# bakers0 and bre%ers0 east It contains these"uences of east $enes and proteinsC descriptions and cassifications of theirbioo$ica roes# moecuar functions# and subceuar ocai*ationsC inks toiterature informationC inks to functiona $enomics datasetsC and toos foranasis and comparison of se"uences

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    http://saf.bio.caltech.edu/model_org.htmlhttp://www.tigr.org/db.shtmlhttp://cgsc.biology.yale.edu/index.phphttp://saf.bio.caltech.edu/model_org.htmlhttp://www.tigr.org/db.shtmlhttp://cgsc.biology.yale.edu/index.php
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    mip*38D: mip* 3!mp#ehen*i"e 8ea*t en!me Databa*e(http@//mips$sfde/$enre/pro2/east/)

    .he MI! &omprehensi-e Heast Genome Database (&HGD) aims to presentinformation on the moecuar structure and functiona net%ork of the entire

    se"uenced# %estudied mode eukarote# the buddin$ east !accharomcescere-isiae In addition the data of -arious pro2ects on reated easts are usedfor comparati-e anasis

    3D: %he #!m!te# Databa*e !& accha#!m7ce* ce#e"i*iae(http@//ruaicshedu/!&D/)

    In order to faciitate a sstematic stud of the promoters and transcriptionare$uator ciseements of the east !accharomces cere-isiae on a $enomicscae# %e ha-e de-eoped a comprehensi-e eastspecific promoter database#!&D &urrent !&D contains 65> e,perimenta mapped transcription

    factor (.?) bindin$ sites and :;6 transcriptiona start sites (.!!) as its primardata entries It aso contains ree-ant bindin$ affinit and e,pression data %herea-aiabe In addition to mechanisms for promoter information (incudin$se"uence) retrie-a and a data submission form# !&D aso pro-ides somesimpe but usefu toos for promoter se"uence anasis

    315B3%E1

    37an!Ba*e: %he en!me Databa*e &!# 37an!bacte#ia(http@//$enomeka*usaor2p/canobase/)

    &anobacteria carr a compete set of $enes for o,$enic photosnthesis#%hich is the most fundamenta ife process on the earth .his or$anism is asointerestin$ from an e-outiona -ie%point# for it %as born in a -er ancient a$eand has sur-i-ed in -arious en-ironments &horopast is beie-ed to ha-ee-o-ed from canobacteria ancestors %ho de-eoped an endosmbionticreationship %ith a eukarotic host ce &anoBase pro-ides an eas %a ofaccessin$ the se"uences and aincusi-e annotation data on the structures ofthe canobacteria $enomes

    #abid!p*i* thaliana

    %1 Databa*e #abid!p*i* thaliana en!me #!ject(http@//%%%ti$ror$/tdb/e;k=/ath=/)

    .he .IG1 Arabidopsis thaiana Database pro-ides access to $enomicse"uence data and annotation $enerated at .IG1 and assembies ofArabidopsis E!.s from %ord%ide se"uencin$ pro2ects

    %1: %he #abid!p*i* 1n&!#mati!n e*!u#ce(http@//%%%arabidopsisor$/)

    .he Arabidopsis Information 1esource (.AI1) maintains a database of $enetic

    and moecuar bioo$ data for the mode hi$her pant Arabidopsis thalianaData a-aiabe from .AI1 incudes the compete $enome se"uence aon$ %ith

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    http://rulai.cshl.edu/SCPD/http://genome.kazusa.or.jp/cyanobase/http://www.tigr.org/tdb/e2k1/ath1/http://www.arabidopsis.org/http://rulai.cshl.edu/SCPD/http://genome.kazusa.or.jp/cyanobase/http://www.tigr.org/tdb/e2k1/ath1/http://www.arabidopsis.org/
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    $ene structure# $ene product information# metaboism# $ene e,pression# DNAand seed stocks# $enome maps# $enetic and phsica markers# pubications#and information about the Arabidopsis research communit Gene productfunction data is updated e-er t%o %eeks from the atest pubished researchiterature and communit data submissions Gene structures are updated =;

    times per ear usin$ computationa and manua methods as %e as communitsubmissions of ne% and updated $enes .AI1 aso pro-ides e,tensi-e inkoutsfrom our data pa$es to other Arabidopsis resources

    %-D Exp#e**: #abid!p*i* gene mapping t!!l (http@//si$nasakedu/c$ibin/tdnae,press)

    A comprehensi-e ist of .DNA mutants of Arabidopsis a-aiabe at differentcoections

    DB: %he lant #!te!me Databa*e(http@//ppdbtccorneedu/)

    DB is a ant roteome DataBase for Arabidopsis thaiana and mai*e (eamas) Initia DB %as dedicated to pant pastids# but has no% e,panded tothe %hoe pant proteome O hence it %as renamed from astid DB to antDB in No-ember ;>>7 .he DB stores e,perimenta data from inhouseproteome and mass spectrometr anasis# curated information about proteinfunction# protein properties and subceuar ocai*ation Important# proteins areparticuar curated for possibe (intra) pastid ocation and their pastid functionrotein accessions identified in pubished Arabidopsis (and other Brassicacea)proteomics papers are crossreferenced to rapid determine pre-iouse,perimenta identification b mass spectrometr

    5t#!* !#gani*m!*:

    13%2dB: %he 4ni"e#*al 2i#u* Databa*e !& the 1nte#nati!nal 3!mmittee !n%ax!n!m7 !& 2i#u*e*(http@//%%%ncbinmnih$o-/I&.db/)

    .he 'ni-ersa irus Database# I&.dB# is authorised b I&. (Internationa&ommittee on .a,onom of iruses) .he director of I&.dB is an Inde, ofiruses# a ist of appro-ed -irus names inked to -irus descriptions coded frominformation in irus .a,onom# and incudes updates subse"uent appro-ed

    b I&. It aso incorporates the pant -irus database IDEdB and is iustrated%ith EM pictures# dia$rams and ima$es of smptoms contributed b -iroo$istsaround the %ord

    97pe#3LDB(http@//%%%biotechistuni$eit/cdb/inde,eshtm)

    4per&LDB is a hperte,t on ce cuture a-aiabiit e,tracted from the &eLine Data Base of the Interab ro2ect It incudes inks to records of MIM# thenine Mendeian Inheritance in Man &atao$ue# and no% aso inks to theubMed# database of bibio$raphic biomedica references# %hich are dra%nprimari from MEDLINE and 1EMEDLINE

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    http://signal.salk.edu/cgi-bin/tdnaexpresshttp://signal.salk.edu/cgi-bin/tdnaexpresshttp://ppdb.tc.cornell.edu/http://www.ncbi.nlm.nih.gov/ICTVdb/http://www.biotech.ist.unige.it/cldb/indexes.htmlhttp://signal.salk.edu/cgi-bin/tdnaexpresshttp://signal.salk.edu/cgi-bin/tdnaexpresshttp://ppdb.tc.cornell.edu/http://www.ncbi.nlm.nih.gov/ICTVdb/http://www.biotech.ist.unige.it/cldb/indexes.html
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    BASES DE DATOS DE PATENTES

    Japane*e atent 5&&ice (J5) (http@//%%%2po$o2p/)

    .he aim of industria propert (I) sstem ($enera term for patent# utiit mode#desi$n# and trademark sstems) is to contribute to the nation0s industriade-eopment throu$h ade"uate protection and effecti-e utii*ation of in-entionsand other forms of inteectua creations .o hep promote science andtechnoo$# the I sstem is e,pected to pa an increasin$ important roe inJapan in the ;=st centur .he Japan atent ffice (J) consists of theGenera Affairs Department# the E,amination Department# the AppeasDepartment# and other sections and departments .he main functions of thesedepartments incudeC =) $rantin$ ade"uate ri$hts for patents# etc# ;) draftin$pans for I poicies#

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    a-aiabe onine -ia the '!. %ebsite Internationa atents are not co-eredb this pa$e

    atentc!pe: ea#ch 1nte#nati!nal atent pplicati!n*(http@//%%%%ipoint/pctdb/en/)

    A.EN.!&E3 !earch !er-ice enabes ou to do fute,t search in o-er =9miion pubished internationa patent appications from the first pubication in=875

    ON-LINE ANALYSIS TOOLS

    BL% (http@//bastncbinmnih$o-/Bastc$i)

    .he BLA!. (Basic Loca Ai$nment !earch .oo) finds re$ions of oca simiaritbet%een se"uences .he pro$ram compares nuceotide or protein se"uences tose"uence databases and cacuates the statistica si$nificance of matchesBLA!. can be used to infer functiona and e-outionar reationships bet%eense"uences as %e as hep identif members of $ene famiies

    3lu*tal'+

    (http@//npsapbiibcpfr/c$ibin/npsaautomatpPpa$eQ/N!A/npsacusta%htm)

    &usta+; is a $enera purpose mutipe se"uence ai$nment pro$ram for DNAor proteins It produces bioo$ica meanin$fu mutipe se"uence ai$nments ofdi-er$ent se"uences It cacuates the best match for the seected se"uences#and ines them up so that the identities# simiarities and differences can be seenE-outionar reationships can be seen -ia -ie%in$ &ado$rams or ho$rams

    Ex7 M!lecula# Bi!l!g7 e#"e# (http@//%%%e,pasch/)

    .his is the E,A! (E,pert rotein Anasis !stem) proteomics ser-er of the!%iss Institute of Bioinformatics (!IB) .his ser-er is dedicated to the anasis

    of protein se"uences and structures as %e as ;D AGE

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    http://www.wipo.int/pctdb/en/http://blast.ncbi.nlm.nih.gov/Blast.cgihttp://npsa-pbil.ibcp.fr/cgi-bin/npsa_automat.pl?page=/NPSA/npsa_clustalw.htmlhttp://npsa-pbil.ibcp.fr/cgi-bin/npsa_automat.pl?page=/NPSA/npsa_clustalw.htmlhttp://www.expasy.ch/http://www.wipo.int/pctdb/en/http://blast.ncbi.nlm.nih.gov/Blast.cgihttp://npsa-pbil.ibcp.fr/cgi-bin/npsa_automat.pl?page=/NPSA/npsa_clustalw.htmlhttp://npsa-pbil.ibcp.fr/cgi-bin/npsa_automat.pl?page=/NPSA/npsa_clustalw.htmlhttp://www.expasy.ch/
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    h7l!gen7. !bu*t h7l!genetic nal7*i* !# %he !n-peciali*t(http@//%%%pho$enfr/-ersion;c$i/inde,c$i)

    ho$enfr is a free# simpe to use %eb ser-ice dedicated to reconstructin$

    and anasin$ pho$enetic reationships bet%een moecuar se"uences

    ho$enfr runs and connects -arious bioinformatics pro$rams to reconstructa robust pho$enetic tree from a set of se"uences

    DB*um(http@//%%%ebiacuk/thorntonsr-/databases/pdbsum/)

    DBsum pro-ides an ata$ance o-er-ie% of e-er macromoecuar structuredeposited in the rotein Data Bank (DB)# $i-in$ schematic dia$rams of themoecues in each structure and of the interactions bet%een them

    3!d!n 4*age Databa*e (http@//%%%ka*usaor2p/codon/)

    11

    http://www.phylogeny.fr/version2_cgi/index.cgihttp://www.ebi.ac.uk/thornton-srv/databases/pdbsum/http://www.kazusa.or.jp/codon/http://www.expasy.ch/images/others/sitemap.gifhttp://www.phylogeny.fr/version2_cgi/index.cgihttp://www.ebi.ac.uk/thornton-srv/databases/pdbsum/http://www.kazusa.or.jp/codon/
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    &odon 'sa$e Database compied from &'.G (&odon 'sa$e .abuated fromGenBank)

    EBE (http@//rebasenebcom/rebase/rebasehtm)

    .he 1estriction En*me Database is a coection of information about restrictionen*mes and reated proteins It contains references# reco$nition and cea-a$esites# isoschi*omers# commercia a-aiabiit# methation sensiti-it# crsta andse"uence data DNA methtransferases# homin$ endonuceases# nickin$en*mes# specificit subunits and contro proteins are aso incuded Mostrecent# putati-e DNA methtransferases and restriction en*mes are asoisted

    SITIOS DE BSQUEDA DE PROTOCOLOS

    M!lecula# 3l!ning: Lab!#at!#7 Manual

    (http@//%%%cshpresscom/defauttpPcartQ=;6;6;;:6 earsof e,perience and o-er ==#6>> protocos# as %e as e,pert Editoria Boards and

    a "uaified inhouse scientific editoria staff# &urrent rotocos is the eadin$source of hi$h"uait protocos for ife scientists %ord%ide

    12

    http://www.cshlpress.com/default.tpl?cart=123905252245382412&fromlink=T&linkaction=full&linksortby=oop_title&--eqSKUdatarq=21#descriptionhttp://www.cshlpress.com/default.tpl?cart=123905252245382412&fromlink=T&linkaction=full&linksortby=oop_title&--eqSKUdatarq=21#descriptionhttp://www.cshlpress.com/default.tpl?cart=123905252245382412&fromlink=T&linkaction=full&linksortby=oop_title&--eqSKUdatarq=21#descriptionhttp://biovisa.net/protocol/protocol_index.php3http://molecularbiology.forums.biotechniques.com/forums/index.phphttp://www.currentprotocols.com/http://www.cshlpress.com/default.tpl?cart=123905252245382412&fromlink=T&linkaction=full&linksortby=oop_title&--eqSKUdatarq=21#descriptionhttp://www.cshlpress.com/default.tpl?cart=123905252245382412&fromlink=T&linkaction=full&linksortby=oop_title&--eqSKUdatarq=21#descriptionhttp://www.cshlpress.com/default.tpl?cart=123905252245382412&fromlink=T&linkaction=full&linksortby=oop_title&--eqSKUdatarq=21#descriptionhttp://biovisa.net/protocol/protocol_index.php3http://molecularbiology.forums.biotechniques.com/forums/index.phphttp://www.currentprotocols.com/
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    E 9ealthca#e #!tein u#i&icati!n 9andb!!k*(http@//%%%6$eifesciencescom/aptri,/upp>>8=8nsf/&ontent/Lab!ep.echDoc;Whandbppr)

    Manuaes de GE 4eathcare de purificaciUn de proteTnas de as diferentestXcnicas de cromato$rafTa

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