Fibrilacion Atrial (1)
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Transcript of Fibrilacion Atrial (1)
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Atrial Fibrillation
BASIC INFORMATIONDEFINITION
Atrial fibrillation (AF) is chaotic atrial activity caused by simultaneous discharge of multiple
atrial foci because of multiple reentrant circuits.
SYNONYMS
AF
A-fib
ICD-9CM CODES
427.31 Atrial fibrillation
EPIDEMIOLOGY & DEMOGRAPHICS
The prevalence of AF increases with age, from 0.1% in adults
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Structural cardiac disease: pericarditis, myocarditis, cardiomyopathy, congestive
heart failure, coronary artery disease, myocardial infarction, congenital heartdisease (especially those that lead to atrial enlargement such as atrial septal
defect), tachycardia-bradycardia syndrome
Arrhythmias: atrial tachycardia, Wolff-Parkinson-White syndrome
Endocrine: thyrotoxicosis, hyperthyroidism or subclinical hyperthyroidism,
pheochromocytoma
Surgery: both cardiac and noncardiac
Electrolytes: hypokalemia, hypomagnesemia
Systemic stress: fever, anemia, hypoxia, sepsis, infections (e.g., pneumonia)
Medications/toxins: digitalis, adenosine, theophylline, amphetamines, cocaine,antihistamines, alcohol abuse and/or withdrawal, caffeine
DIAGNOSISDIFFERENTIAL DIAGNOSIS
Multifocal atrial tachycardia
Atrial flutter
Frequent atrial premature beats
WORKUP
New-onset AF: ECG, echocardiogram, Holter monitor (selected patients), and laboratory
evaluation
LABORATORY TESTS
Thyroid-stimulating hormone, free T4
Serum electrolytes
Toxicity screen
IMAGING STUDIES
ECG (see Fig. 1-33 for atrial flutter and fibrillation)
Absence of P waves
Fibrillatory or f waves at the isoelectric baseline with varying amplitude,
morphology, and intervals
Irregular ventricular rate
Echocardiography to rule out structural heart disease (evaluate ventricular size,
thickness, and function, atrial size, and valve function)
Holter monitor: useful only in selected patients to evaluate paroxysmal AF
TREATMENT
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NONPHARMACOLOGIC THERAPY
Avoidance of alcohol in patients with suspected excessive alcohol use
Avoidance of caffeine and nicotine
Treatment of underlying source/cause, if any found
The Maze surgical procedure, with its recent modifications creating electricalbarriers to the macroreentrant circuits that are believed to underlie AF, is being
performed with good results in several medical centers (preservation of sinusrhythm in >95% of patients without the use of long-term antiarrhythmic
medication). Clear indications for its use remain undefined. In general, surgery isreserved for patients with rapid heart rate refractory to pharmacologic therapy or
those who cannot tolerate pharmacologic therapy.
Pulmonary vein ablation for chronic AF: Sinus rhythm can be maintained longterm in the majority of patients with chronic AF by circumferential pulmonary
vein ablation, independently of the effects of antiarrhythmic drug therapy,cardioversion, or both. The American College of Cardiology/American Heart
Association/European Society of Cardiology (ACC/AHA/ESC) guidelines statethat catheter ablation is a reasonable alternative to medical therapy to prevent
recurrent AF in symptomatic patients in the absence of significant left atrialenlargement (class 2A recommendation).
ACUTE GENERAL Rx
New-onset AF:
If the patient is hemodynamically unstable (hypotension, congestive heart failure
or angina), perform synchronized cardioversion after immediate conscioussedation with a rapid short-acting sedative (e.g., midazolam). The likelihood of
cardioversion-related clinical thromboembolism is low in patients with AF lasting2 days have a 5% to 7% risk for clinical
thromboembolism if cardioversion is not preceded by several weeks of warfarintherapy. However, if transesophageal echocardiography reveals no atrial
thrombus, cardioversion may be performed safely after anticoagulation has beenachieved. Anticoagulant therapy should be continued for at least 1 mo after
cardioversion to minimize the incidence of adverse thromboembolic events. It canbe stopped as long as AF has not recurred.
If the patient is hemodynamically stable, a rate-control strategy is typically
pursued initially. Treatment options include the following:
1. Diltiazem 0.25 mg/kg (maximum of 25 mg) given intravenously (IV)over 2 min followed by a second dose of 0.35 mg/kg (maximum of 25mg) 15 min later if the rate is not slowed to
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can be changed to oral diltiazem 60 to 90 mg q4-6h.
2. Verapamil 2.5 to 5 mg IV initially, then 5 to 10 mg IV 10 min later if the
rate is still not slowed to
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undergo anticoagulation, low-dose aspirin is an appropriate alternative in these
patients.
For patients in whom anticoagulation with warfarin is contraindicated, aspirin plusclopidogrel has been shown to be of similar benefit in reducing thromboembolic
events as warfarin (Coumadin) with a similar bleeding risk.
DISPOSITION
Factors associated with maintenance of sinus rhythm after cardioversion include:
Left atrium diameter
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Both transesophageal echocardiography with short-term prior anticoagulation
followed by early acute cardioversion (in absence of intracardiac thrombus) withpostcardioversion anticoagulation vs. delayed cardioversion with
preanticoagulation and postanticoagulation are appropriate management strategiesfor patients who elect to undergo cardioversion.
EVIDENCE
There is evidence for similar mortality and cardiovascular morbidity in olderasymptomatic patients with chronic AF treated with either a rate-controlling therapy
or rhythm-controlling therapy.
Five randomized controlled trials have found similar mortality rates between
asymptomatic patients with rate-controlled vs. rhythm control chronic AF.[[1]]
Warfarin is effective for both the primary and secondary prevention of ischemicstroke and TIA in patients with chronic AF. General recommendations are as
follows:
In people with persistent or intermittent AF with a CHADS2 score of 2,
anticoagulation with an oral vitamin K antagonist, such as warfarin, isrecommended (target international normalized ratio, 2.5; range, 2.0 to 3.0).
[[2]]
In people with persistent or intermittent AF with a CHADS2 score of 1,
anticoagulation with either an oral vitamin K antagonist, such as warfarin, oraspirin therapy is recommended.
[[2]]
Primary prevention of stroke in patients at high risk:
Adjusted-dose warfarin is significantly more effective than placebo in reducingthe risk for stroke in people at high risk for stroke.
[[3]]
Adjusted-dose warfarin is significantly more effective than aspirin in reducingthe risk for ischemic stroke or systemic embolism in patients at high risk for
stroke.[[3]]
Primary prevention of stroke in patients at lower risk:
Adjusted-dose oral anticoagulation is significantly more effective than placebo
in reducing overall stroke, disabling or fatal stroke, and death in patients withnonvalvular AF and no prior history of strokes or TIA. The combined end
point of all stroke, myocardial infarction, or vascular death was also reduced.The observed rates of intracranial and extracranial hemorrhage were not
significantly increased, but confidence intervals were wide.[[4]]
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Secondary prevention of stroke:
Anticoagulants are significantly more effective than antiplatelet therapy in
reducing all vascular events and also recurrent stroke in patients with
nonrheumatic AF and a history of minor ischemic stroke or TIA. The risk formajor extracranial bleeds, but not intracranial bleeds, appears to be increasedin patients on anticoagulants.
[[5]]
Dronedarone is a newer, recently approved agent that is pharmacologicallysimilar to amiodarone with less toxicity. A recent multicenter, double blind
trial showed that dronedarone was more effective than placebo in maintainingnormal sinus rhythm
[[6]]and in reducing cardiovascular events.
[[7]]However,
dronedarone is not indicated in patients with severe heart failure and leftventricular systolic dysfunction (ejection fraction